There is a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to decrease afferent pain transmission and deliver analgesia. As a result, drugs like clonidine that target alpha-2 receptors can affect the transmission of discomfort. : connected to, served by, https://simonpomgb.blogmazing.com/31409374/the-2-minute-rule-for-onolidine