Opioid action is because of each lower affinity binding with the parent compound and better affinity binding of the O-demethylated metabolite M1 to μ-opioid receptors. In animal types, M1 is up to 6 moments extra strong than tramadol in making analgesia and 200 occasions more potent in μ-opioid binding. When https://emilyq975kpl3.daneblogger.com/profile